Utilising Pi3k/Akt-Dependent Senescence to Treat Cancer

The potential of targeting ribosome biogenesis in high-grade serous ovarian cancer

S Yan, D Frank, J Son, KM Hannan, RD Hannan, KT Chan, RB Pearson, E Sanij

2017-01-20

Overall survival for patients with ovarian cancer (OC) has shown little improvement for decades meaning new therapeutic options ar..

Combining high-content imaging and phenotypic classification analysis of senescence-associated beta-galactosidase staining to identify regulators of oncogene-induced senescence

KT Chan, L Paavolainen, KM Hannan, AJ George, RD Hannan, KJ Simpson, P Horvath, RB Pearson

2016-09-01

Hyperactivation of the PI3K/AKT/mTORC1 signaling pathway is a hallmark of the majority of sporadic human cancers. Paradoxically, c..

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

J Kang, EP Kusnadi, AJ Ogden, RJ Hicks, L Bammert, U Kutay, S Hung, E Sanij, RD Hannan, KM Hannan, RB Pearson

2016-01-01

Dysregulation of RNA polymerase I (Pol I)-dependent ribosomal DNA (rDNA) transcription is a consistent feature of malignant transf..

Regulation of rDNA transcription in response to growth factors, nutrients and energy

EP Kusnadi, KM Hannan, RJ Hicks, RD Hannan, RB Pearson, J Kang

2015-01-01

Exquisite control of ribosome biogenesis is fundamental for the maintenance of cellular growth and proliferation. Importantly, syn..